Angiogenesis is regulated by many complementary and complex signaling pathways in the human body. Vascular Endothelial Growth Factor (VEGF)-Vascular Endothelial Growth Factor Receptor (VEGFR), Angiopoietin (Ang)-Tie2 Axis and Dll4-Notch 3. Three complex, complementary signaling pathways play an important role in regulating angiogenesis.
VEGF binds to the high affinity of the two receptors KDR and Flt-1 on endothelial cells, directly stimulates the proliferation of vascular endothelial cells, induces migration and forms a cavity-like structure; it also increases microvascular permeability and causes plasma proteins ( It is mainly fibrinogen) extravasation and promotes neovascularization in vivo by inducing interstitial production. VEGF plays a central regulatory role in angiogenesis and formation and is a key angiogenic stimulator. Basic fibroblast growth factor (bFGF). TNF-α is a vasoactive cytokine that induces the release of ectopic endometrial inflammatory cytokines MCP-1, IL-6 and IL-8, and promotes ectopic endometrial and stromal cell proliferation and inflammation. Sexual cell infiltration, neovascularization, tissue adhesion, and the formation of ectopic lesions.
The signal molecules involved in this signal transduction mainly include:
HIF1α, PHDs, HIF1β, PI3K, Akt, mTOR, S6K, 4E-BP1, eIF4E1, elF4E1, Ras, MEK1, MEK2, Erk1, Erk2, MNK, CBP, P300, TCEB1, TCEB2, Rbx1, Cul2, VHL, MMP, Cox2, PAI-1, VEGF, PDGFR-β, VEGFR2, Tie2, FGFR, IGFR, TGFα-R, SLIT, ROBO, Src, FAK, p38, MAPK, Smad2, Smad3, PLCγ, NOS, and the like.
Click on the signal molecule in the picture to automatically find the relevant reagent
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