Changes in laboratory knockout mice

Although studies have shown that laboratory mice are a valuable model for physiology and pathology studies, this animal has undergone changes that differ from its wild ancestors with long-term inbreeding. Compared to wild-type mice, laboratory mice were "greater, fatter, calmer, less aggressive" and these animals have lost the characteristics of some wild-type mice.

“Laboratory mice are easy to manipulate and multiply, are relatively inexpensive, and have powerful genetic models, behavioral patterns, and genome sequencing sequences,” said Stephen Liberles, a cell biologist from Harvard University (not involved in the study), “( But this study) points to the importance of some of the natural diversity of wildlife groups."

The Institute selected wild and mouse mice to progeny after ten generations of breeding, and analyzed the behavioral differences. The study helped researchers find some special behaviors that are currently lost in laboratory mouse populations, especially females.

Female wild mice violently attack foreign creatures that are not members of their family, but laboratory mice are often able to adapt to this situation and take care of foreign creatures. The researchers also discovered a genetic component that affects behavioral changes: TrpC2, which is present in the wild pheromone of wild mice, but laboratory mice do not have similar functions.

For many years, laboratory mice have helped us a lot, answering many medical problems, researching neurobiologists, but for some problems, such as female aggression, these mice may no longer be the best model. It is. ”

Similarly, researchers have previously pointed out that the gene expression of mouse models does not mimic human inflammatory diseases such as severe burns, sepsis and acute infections.

This study focused on genes that have changed in human disease and compared their expression levels between humans and mice. But recent research indicates that they have not considered whether genes have changed in mouse models. When comparing human and mouse genomic responses, genes that only change in one organism should not be included.

More studies have shown that human disease and mouse models have many common molecular pathway failures. The commonality between human disease and mouse models can provide us with valuable information to reveal the pathological process and pathogenesis of human diseases, and develop new therapeutic strategies based on this.


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