Medicinal plastic bottle "show" charm

Editor's Note: Drugs as a class of special products play an important role in maintaining public health, and their quality has been closely watched by governments of all countries. Since the active chemicals in drugs play a role, its stability is directly affected by the packaging materials and packaging forms. Therefore, the packaging of pharmaceuticals must pay attention.

In recent years, pharmaceutical plastic bottle packaging has developed rapidly. Medicinal plastic bottles continue to conquer the special fields of pharmaceutical packaging because of their light weight, no damage, and good hygiene.

Therefore, we borrowed the last issue (plastic in the medical packaging industry ) and then “showed” the unique charm of a medicinal plastic bottle!

â—† medicinal plastic bottles commonly used materials â—†

The material of plastic itself is divided into PE, CPP, BOPE, BOPET, BOPA and so on. Due to its strong comprehensive advantages and unparalleled superiority of other materials, it has been generally welcomed, although it will cause some harm to the environment. Its usage has increased rapidly and has partially replaced glass infusion bottles and other materials. Drug manufacturers may select the appropriate pharmaceutical packaging based on the barrier properties of the drug against the packaging materials and the packaging of the drug, taking into account other factors such as transparency, aesthetics, ease of taking the drug, and economy. Plastic packaging containers are packaging materials that come in direct contact with pharmaceuticals. Therefore, in order to ensure that pharmaceutical packaging materials can be used to package pharmaceuticals, it is necessary to monitor the quality of these materials.

Medicinal plastic bottles commonly used plastic raw materials

1. Polyolefins: Polyolefin plastic raw materials suitable for making pharmaceutical plastic containers include: polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene (PS). Among them, polyethylene includes: high-density polyethylene (HDPE), medium-density polyethylene (MDPE), low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE); polystyrene includes high-impact polystyrene (GPPS-HIPS).

2. Polyester: Polyester plastic raw materials mainly include poly(ethylene terephthalate) (PET), polycarbonate (PC), and poly(p-butylene naphthalate) (PEN).

3, colorant and processing aids: The colorant of the bottle is usually selected titanium dioxide TiO2 (anatitanium or rutile), TiO2 content of ≥ 98% Wt, added amount of 1.0% ~ 1.5% Wt.

Packaging materials, especially packaging materials that are in direct contact with the drug, play a decisive role in ensuring the stability of the drug. Therefore, the applicability of the material will directly affect the safety of the drug. Unsuitable materials can cause migration, adsorption, adsorption, and even chemical reactions of active pharmaceutical ingredients, leading to drug failure and sometimes serious side effects. Therefore, before selecting the container material for a drug, it must be verified whether it is suitable for the intended use.

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â—† Quality control of medicinal plastic bottles

※ (a) design molding

The application of high-quality medicinal plastic bottles is inseparable from reasonable bottle structure design, perfect production equipment and mature process methods.

In the bottle formulation design, first determine whether the plastic raw material can meet the requirements of equipment molding. Whether the melt index and the physical and chemical indicators of plastic raw materials can meet the performance of the finished product. At present, the main raw materials used are high-density polyethylene (HDPE) and polypropylene (PP). Such crystalline plastics have good impact resistance, environmental stress resistance, chemical resistance, and good gas barrier properties and resistance. Wet and non-toxic. Followed by the use of plastic compounding agents such as: sunscreens, colorants, plasticizers and so on.

At present, the shape of medical plastic bottles is round, square, oval and so on. The round bottle body has the largest amount of use. Its characteristic is that the wall thickness is relatively uniform, the ability to absorb impact energy is high, and the production cost is low, but the utilization rate of the effective area during storage or transportation is low. The effective area of ​​the square or rectangular bottle is high in the utilization rate and the stability is good, but the bulging phenomenon is more likely to occur. The specifications of plastic bottles are not yet clearly defined and are generally based on the needs of users and the nature of the drugs. In addition to the nominal capacity of plastic bottles,