Peel off the eggs and you will see the protein. How can you see their molecular structure? How do you figure out how tens of thousands of proteins work? This is related to human understanding of the nature of life and one of the most important issues facing life scientists worldwide.
In Zhangjiang, Shanghai, a world-class protein science research platform is beginning to take shape. A few days ago, during the "Public Science Day" of the Chinese Academy of Sciences, the reporter walked into the state-level large-scale scientific facilities under construction, and explored the cutting-edge equipment and advanced technology.
Resolution reduced from hours to 2 minutes and a half
Shi Yigong, a world-famous structural biologist and professor at Tsinghua University, once said that for structural biology, getting a protein structure is only the starting point. And to get a protein structure, it usually takes about one year for a research group.
“This is because all work must be done manually.†Lei Ming, a researcher at the Institute of Biochemistry and Cell Research at the Shanghai Academy of Sciences, Chinese Academy of Sciences, told reporters that protein research is still in the “hand workshop†stage, and he hopes to make this field enter as soon as possible. The Industrial Age" - Scientists place orders for a protein structure, and smart factories will quickly send data to the desk.
Since June 2011, when he was introduced to the country with the “Thousand Talents Programâ€, Lei Ming became the director of the National Protein Science Center·Shanghai, and he began to implement this idea. Nowadays, this “smart factory†for protein analysis has taken shape in the protein science research (Shanghai) facility – a set of self-designed, globally unique gene cloning automation devices that can be used to clone 960 genes a day. Traditional manual operation can complete up to a dozen per person per day; protein replication, purification, and even crystallization are all done by robots; on the special line of protein research in Shanghai Light Source, with the help of newly developed automation software, take a shot for protein molecules. Zhang Zhao takes only 0.1 seconds, and it takes only 36 seconds to get a set of data. The parsing structure only takes 2 minutes and a half...
"Light" gently pulls open the protein molecules
In the foreseeable future, the fine-to-atomic protein structure will be continuously distributed to the world, and life science research will enter a new generation. As a national protein science center in Shanghai supporting the protein Shanghai facility, Shanghai has prepared a first-class scientific research platform for protein research.
Huang Chaolan is a high-end talent specially introduced from overseas. She has brought a world-class mass spectrometry team to the center, and this technology is indispensable in almost any life science research. Shortly after joining Zhou Zhongwen, a tenured professor of Harvard Medical School, he analyzed the important proteins in hepatitis C virus and opened up a new direction for hepatitis C treatment. The center has cooperated with top animal facilities to establish experimental animal platforms such as fruit flies and mice, and conduct more in-depth protein research from the cell and tissue levels.
In the Optical Laboratory, the reporter saw a system developed exclusively by the center's researchers. It puts the two ends of the protein into microspheres with a diameter of 2 microns, and uses a laser as a "scorpion" to gently pull the protein apart. See how the protein folds.
Lei Ming said that he hopes that in this 45-acre science park, not only will a group of scientific research and scientists leading the world's protein research be born, but also a series of protein-related high-tech industries.
National Protein Science Center·Shanghai (Finance)
National Protein Science Center·Shanghai (Finance) is China's first comprehensive national-level major technology infrastructure in the field of life sciences. In November 2008, the project was included in the national high-tech industry development project plan, and construction began in December 2010. The total investment of the project is 700 million yuan, and the total construction area of ​​the project is 33,000 square meters. The Shanghai Institute of Life Sciences of the Chinese Academy of Sciences undertakes the construction task and builds the National Protein Science Center·Shanghai based on the Shanghai facility.
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