Chinese Academy of Sciences Shenzhen Advanced Institute and other research and development of intravascular ultra-high resolution photoacoustic microscopy system

Recently, the Shenzhen Advanced Institute of the Chinese Academy of Sciences has cooperated with the Laotebo Biomedical Imaging Research Center and the Li Ka Shing Medical College of HKU to make new progress in the field of intravascular imaging. The R & D team is the first in the world to successfully develop an intravascular ultra-high resolution photoacoustic micro-imaging system with an imaging resolution of up to 19.6 μm, which is expected to provide innovative technical means for the interventional diagnosis and treatment of acute cardiovascular and cerebrovascular events.

Acute cardio-cerebrovascular events such as acute myocardial infarction and stroke have become a hidden threat to human health, and nearly 70% of acute cardiovascular events are caused by the formation of thrombosis due to the rupture of vulnerable plaque in coronary arteries. Realizing early diagnosis and early warning of vulnerable plaque is one of the keys to reducing the mortality of cardiovascular and cerebrovascular diseases. At present, the coronary angiography, intravascular ultrasound, and optical coherence tomography techniques used in clinics can only obtain the morphological and structural information of blood vessels, and cannot accurately obtain the composition information and inflammatory activity of intravascular plaques, which has caused the rupture of plaques during evaluation. Risks and deficiencies in guiding interventional therapy.

In response to the urgent needs of intravascular interventional imaging, the R & D team of the Chinese Academy of Sciences designed and developed an intravascular optical resolution photoacoustic microscopy system, and tested and verified the performance of the system together with the R & D team of HKU. The system is based on photoacoustic imaging technology, which can detect the ultrasonic signals generated by the selective absorption of pulsed laser light by biological tissues to obtain information reflecting important physiological functions such as tissue composition and inflammatory activity, and guide the interventional diagnosis and treatment of cardiovascular diseases. It is extremely significant. In addition, the system can also obtain conventional intravascular ultrasound images at the same time, providing morphological and structural information of the entire vessel inner wall.

The microscopic system developed by the R & D team has an outer diameter of only 1.1mm for the imaging catheter of the system, and the design of flexibility and biocompatibility has basically met the requirements for clinical use. In addition, the spatial resolution of the photoacoustic microscopic imaging measured in the experiment is as high as 19.6mm, which is about 10 times higher than the resolution of traditional intravascular photoacoustic and ultrasound imaging. It can obtain ultra-high resolution images comparable to intravascular OCT. And evaluation of cardiovascular stent placement has shown great potential applications. At the same time, the system can accurately identify the plaque lipids, fibers and other components through photoacoustic spectroscopy imaging, which has a very high scientific research and clinical guidance for further improving the early identification, diagnosis and treatment of vulnerable plaque in intravascular imaging. Value.

At present, the team has applied for 5 Chinese invention patents and 2 international invention patent PCT for this technology, laying a foundation for the clinical and industrial transformation of relevant independent intellectual property rights.

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